上皮性卵巢癌组织中CD44、Nanog的表达及临床意义

发布于:2021-10-17 13:22:56

龙源期刊网 http://www.qikan.com.cn 上皮性卵巢癌组织中 CD44、Nanog 的表达 及临床意义 作者:杜文升 魏敏 来源:《中国医药导报》2018 年第 35 期 [摘要] 目的 探讨上皮性卵巢癌组织中 CD44、转录因子 Nanog 的表达水*及其临床意义。 方法 收集 2012 年 1~12 月于徐州医科大学附属医院行手术治疗的 80 例上皮性卵巢癌患者的卵 巢组织标本为病例组,并于同期随机选取 60 例良性卵巢肿瘤患者卵等组织标本为对照组。采 用免疫组织化学法检测各组标本中 CD44、Nanog 的表达水*。 结果 病例组 CD44、Nanog 阳 性表达率均高于对照组,差异有统计学意义(P <; 0.05)。肿瘤直径≥3 cm、肿瘤低分化、浸 润深度 T3+T4 期、FIGO 分期Ⅲ+Ⅳ期、有淋巴结转移的上皮性卵巢癌患者组织中 CD44、 Nanog 阳性表达率高于肿瘤直径<;3 cm、中高分化、浸润深度 T1+T2 期、FIGO 分期Ⅰ+Ⅱ期、 无淋巴结转移患者,差异均有统计学意义(P <; 0.05)。Spearman 秩相关分析显示病例组患者 组织中 CD44 与 Nanog 表达呈正相关(rs = 0.592,P <; 0.05)。CD44 阳性表达者 5 年生存率 低于 CD44 阴性者,Nanog 阳性表达者 5 年生存率低于 Nanog 阴性者,差异有统计学意义(P <; 0.05)。 结论 CD44、Nanog 表达上调参与了上皮性卵巢癌的发生、发展过程,早期检测可 作为临床辅助诊断上皮性卵巢癌、评估病情严重程度及预测预后的重要标志物。 [关键词] 上皮性卵巢癌;CD44;Nanog;临床意义 [中图分类号] R737.31 [文献标识码] A [文章编号] 1673-7210(2018)12(b)-0082-05 [Abstract] Objective To explore the expression levels of CD44 and transcription factor Nanog in tissues with epithelial ovarian cancer and its clinical significance. Methods A total of 80 ovarian tissues of patients with epithelial ovarian cancer treated by operation in Affiliated Hospital of Xuzhou Medical University from January to December 2012 were collected as case group. At the same time, 60 ouarian tissues of patients with benign ovarian tumors were randomly selected as control group. The expression levels of CD44 and Nanog of two groups were detected by immunohistochemistry. Results The positive expression rate of CD44 and Nanog in case group were both higher than the control group, the differences were statistically significant (P <; 0.05). The positive rate in patients with tumor diameter ≥ 3 cm, low differentiation, T3+T4 stage of infiltration depth, FIGO stage Ⅲ+Ⅳ, lymph node metastasis were higher than those with tumor diameter <;3 cm, medium and high differentiation, T1+T2 stage of infiltration depth, FIGO stage Ⅰ+Ⅱ, no lymph node metastasis, the differences were statistically significant (P <; 0.05). Spearman rank correlation analysis showed that a positive correlation between CD44 and Nanog expression in case group was found (rs = 0.592, P <; 0.05). The 5-year survival rate in patients with CD44 positive expression was lower than that in patients with CD44 negative expression, and the 5-year survival rate in patients with Nanog positive expression was lower than that in patients with Nanog negative expression, the differences were statistically significant (P <; 0.05). Conclusion The up-regulated 龙源期刊网 http://www.qikan.com.cn expression of CD44 and Nanog is

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